Measurement Of Antimicrobial Agents Levels In Body Fluids

Accurate measurement of serum concentrations of antimicrobial agents is important when the margin between therapeutic and toxic levels is narrow. The values given for serum and urine were obtained from normal adults in controlled phar macologic studies table 1. Most distribute well into various body fluids do not distribute well into csf unless meninges are inflamed.

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Measurement of antimicrobial agents levels in body fluids. Antimicrobial levels and renal function for most antimicrobial agents renal excretion is the major pathway for elimination from the. Microbioassay of antimicrobial agents haroldj. Levels correlated with a statistically significant improvement in clinical outcome and a lower mortality. Poor clinical response being correlated with levels lower than the mic of the specific pathogen 12 15.

Jong yin department ofcommunity medicine schoolofmedicine university ofcalifornia sandiego lajolla california 92037 received for publication 10november 1969 apreviously described agar diffusion technique for microbioassay ofantimicro. Persistent suppression of bacterial growth after limited exposure to an antimicrobial agent 1. Laboratory tests that are usually considered helpful in guiding antimicrobial therapy include antimicrobial agent susceptibility tests determination of bacterial production of beta lactamase and assay of specific antimicrobial levels in serum and other body fluids. Chisholm gd waterworth pm calnan js garrod lp.

Constitutive inducible produced at low level wo stimulus. Measurement of antimicrobial agents in serum and body fluids biological assys immunoassays. Concentration of antibacterial agents in interstitial tissue fluid. Production greatly increased after.

For the other body fluids listed the subjects were generally hospitalized patients table 2. In contrast dilution methods allow determination of the minimal inhibitory concentration of an agent which can be correlated with blood urine and other body fluid levels of the antimicrobial agent. These studies suggest that the level of antimicrobial drug in sputum and bronchial secretions is of clinical impor tance. If the tracer is metabolised a series of measurements can be made and assuming exponential decline first order kinetics the volume of distribution can be determined by extrapolation back to zero time.

With the availability of rapid accurate assays the measurement of antibiotic material in serum and other body fluids is feasible desirable and widely practiced for these purposes. The measurement of antibiotic concentrations in various fluids has been a prominent aspect of the evaluation of new antibiotics and the quality control of their manufacture. Measurement of antimicrobial agents in serum and body fluids. 4efficacy or toxicity is delayed or difficult to measure 5accurate assay is available.

A simple micro agar diffusion method for the determination of antibiotic concentrations in blood and other body fluids. Not interfere with body fluid distribution if the tracer is excreted in the urine then the loss can be determined and corrections made in the calculation.